Welcome Back Mural
This easter egg can be seen in both Single and Multiplayer.
In Chamberlain Hills, there is a big mural welcoming players back to Los Santos.
On the mural there are also the letters, “SA 88” and the message, “We Missed you last time”. The 88 is a reference to Franklin Clinton’s birth date and the “we missed you last time” message, along with the two smoking guns held by the skull are a joke meant to say that since you made it out alive in GTA: San Andreas, you won’t this time.
Incidentally, in GTA: San Andreas the 88th mission was titled, “Home Coming”.